Biodynamic Interfaces Are Essential for Human–Environment Interactions

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.

Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact to mediate mitochondrial fusion. To address this issue, we have analyzed the yeast mitofusin Fzo1p and find that mutation of any of the three h...

Ultrasonic Wave Interactions with Interfaces

Essential medicines are still essential.

On Oct 21, WHO published the full report of the 20th Expert Committee on the Selection and Use of Essential Medicines, with its new WHO Model List of Essential Medicines (EML). The new list includes recently developed medicines for drug-resistant tuberculosis (bedaquiline and delamanid), a number of new cancer treatments (such as imatinib, rituximab, and trastuzumab), and, perhaps most controve...

Robust Controller Design for Cancelling Biodynamic Feedthrough

There are many manual control tasks in which the operator base moves in response to joystick movement. Base motion feedback can interfere with the joystick and operator dynamics, resulting in instability and reduced performance. This paper proposes a novel approach to the cancellation of such “biodynamic feedthrough”. A model-based approach is used to formulate a μ-synthesis robust performance ...

A Practical Biodynamic Feedthrough Model for Helicopters

Biodynamic feedthrough (BDFT) occurs when vehicle vibrations and accelerations feed through the pilot’s body and cause involuntary motion of limbs, resulting in involuntary control inputs. BDFT can severely reduce ride comfort, control accuracy and, above all, safety during the operation of rotorcraft. Furthermore, BDFT can cause and sustain Rotorcraft-Pilot Couplings (RPCs). Despite many studi...